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On-X Life Technologies, Inc. (On-X LTI) is committed to restoring the patient’s quality of life by developing, manufacturing and marketing products that are unsurpassed in quality and performance.

On-X LTI, a privately held company, was founded in 1994 and is located in Austin, Texas.

The primary focus of On-X LTI is threefold:

  • Continually improve pyrolytic carbon coating technology along with supporting processing and inspection technologies,
  • Advance the level of prosthetic heart valve performance while reducing the level of patient valve related complications, and
  • Provide additional cardiac surgery products that uniquely improve patient care.

The On-X LTI story is unique among medical device companies because On-X LTI’s management and production teams have been at the forefront of the tandem technologies of carbon biomaterials and prosthetic heart valve design since the 1960’s. Our state-of-the-art On-X valve is attracting worldwide attention for its outstanding clinical performance.

On-X LTI also collaborates with a number of companies to develop and manufacture components for their products utilizing our proprietary and leading edge pyrolytic carbon processing technologies.

 

www.onxlti.com

On-X Design Features

Design features

Every aspect of the On-X valve plays a role in maximizing benefits for the recipient. The scope of innovations in the design reflects the MCRI’s commitment to perfection in creating the On-X Prosthetic Heart Valve.

On-X Carbon
Natural Length
Inlet Flare
Stasis-Free Pivots
Full Opening Leaflets
Soft Closure
Leaflet Guards
Full Annulus Support


On-X Carbon

The purity and finish of On-X carbon coatings assures the greatest biocompatibility for the On-X valve design. The human body does not react against its pure carbon surfaces. Advanced processing technology yields highly polished and contoured features in the critical pivot area, which minimizes opportunities for clots to form or adhere.

onx carbon Design Features

 


Natural lenght

The unique aspect ratio of On-X valves is a crucial element of the comprehensive On-X valve design strategy for maximizing benefits to the patient. Its length-to-diameter ratio approaches that of a native valve.

l d ratio d Design Features

Somewhat counter-intuitively, its greater length (or height) actually reduces turbulence and increases flow. It also allows for reduced leaflet excursion to reduce backflow losses, provides leaflet protection and protects the valve opening from tissue encroachment.


Inlet flare

On-X valve is the first prosthetic heart valve to successfully incorporate a flared inlet, the well-known fluid dynamic principle for producing smooth, organized flow with reduced turbulence. The flare produces an increased volume of flow, comparable to that of a larger orifice.

 

InletFlare clip image001 Design Features

Because the inlet flare extends through the annulus, it is not compromised by encroaching annular tissue and thus maintains the favorable annular shape for a lifetime of consistently optimal flow.


Stasis-free

Pivots are a potential site of clot formation because of possible stasis (flow stagnation). The On-X design provides increased washing throughout the pivot to eliminate areas of potential flow stagnation.

stasis free pivots Design Features

Optimal pivot cleansing is accomplished by introducing flow paths between the leaflet and the pivot wall. The backflow channels are carefully designed to avoid hemolysis. Backflow over smooth, blended contours is key to the low thrombosis rate of the On-X valve.


Full opening leaflets

On-X valve leaflets are free to follow the flow. Other valves must stop short of the fully open position to ensure that they will close reliably with backflow, which can increase obstruction and turbulence .

With the On-X valve’s patented “actuated pivot design”, closure is assured even when leaflets are open to the full 90°. Leaflet freedom reduces turbulence and its accompanying effects such as pressure loss and blood damage.

act pivot Design Features

Optimal pivot cleansing is accomplished by introducing flow paths between the leaflet and the pivot wall. The backflow channels are carefully designed to avoid hemolysis. Backflow over smooth, blended contours is key to the low thrombosis rate of the On-X valve.

Soft closure

The On-X valve has patented two-point “soft landing” leaflets to reduce blood stress in three ways.

  • The two points are closer to the pivots so that the closing impact velocity is reduced by 40%.
  • The two-point landing distributes the closing impulse so that the impact is glancing rather than direct.
  • This “soft landing” minimizes the potential for cavitation that can damage blood.

SoftClosure clip image001 Design Features

Soft Landing also minimizes the potential for noise.


Leaflet guards

The leaflet guards on the On-X valve extend the orifice to form an effective barrier, which protects the leaflet motion from impingement by tissue. This is particularly important in the mitral position when chordae tendinae are preserved. The On-X valve is the only valve with leaflet guards that offer this degree of protection

LeavletGuards clip image001 Design Features


Full Annulus Support
Short valves are vulnerable to tissue ingrowth (pannus) that can compromise valve function. On-X valves provide unprecedented protection from tissue impairments on both the inflow and outflow sides. The valve body extends fully through the annulus to preserve full functionality.

full annulus Design Features

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